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When it comes to modern heating and cooling, homeowners have plenty of options. There are innumerable HVAC manufacturers, different brands, and lots of new technology to heat, cool and ventilate any building in any weather. One fundamental decision a homeowner may make when it comes to an air conditioner or heat pump has to do with coolant. Typically, that choice is between R-22 and R-410a refrigerant. These refrigerants both work effectively, but they are quite different. Some homeowners have questions like:
Can I use R-22 and R-410a refrigerant simultaneously??!
No!
I mean, technically you can do anything. You can step into traffic, jump off a bridge, gargle arsenic, or paste bread to your face before running into a flock of seagulls.
But can does not mean should. For the record, you should not do any of those. They're bad things, and you could die. Seagulls are mean.
Why?
R-22 and R-410a are both refrigerants, true. They can both be used in air conditioners or heat pumps to cool your home during summer. Most people probably have no idea which refrigerant their home even uses and you'd have to be psychic to be able to determine by feel alone which a given system was using.
But, and this is a big but, the two are not the interchangeable. You should never, ever try to mix them in the same system, or use them in a system not rated specifically for that kind of refrigerant.
But, why?
R-410a is designed to operate at higher pressures than R-22. If you use R-22 in the same system as R-410a, the compressor is going to be trying to work two different fluids through the same coils as both refrigerants respond differently to different mechanical situations. As you might imagine, this isn't going to go well for your air conditioner or heat pump.
Long story short? Never mix R-22 and R-410a. Unless of course you are looking to destroy your HVAC system, then, by all means, go live that dream.
Your "humorous" wording is causing VERY misleading google results. When asking google "what refrigerant can be mixed with R410a", your verbiage of "You can mix R-22 and R-410a refrigerant in the same system" is shown as the answer. You really should correct this for those that take the google answers for face value.
It's best to purge the entire system and refill it with one refrigerant. That being said, certain systems are designed for certain refrigerants, so this refrigerant may not work without different valves to accommodate for different refrigerant requirements.